Biochemistry

This course examines cutting edge research into some of the hottest topics and most rapidly advancing areas in biology. Focusing on functional genomics and epigenetics in the context on development, cellular differentiation, disease, non-model organisms and gene-environment interactions. Emphasis on molecular mechanisms and state-of-the-art genomic technologies are underpinned by an understanding of the importance of computational biology in delineating genome function.

Topics include 1. Structural and Molecular Biology: The structures of biomacromolecules (DNA, RNA and proteins), structure determination (NMR, X-ray crystallography and CryoEM), post translational modification of proteins, synthetic gene design, recombinant protein expression, mutagenesis, unnatural amino-acids, methods of purification and characterization including electrophoretic methods and mass spectrometry. 2. In Silico Methods: Sequence analysis, databases, structure prediction and molecular dynamics. Some of the material in this section are delivered as a workshop to foster the development of in silico skills. 3. Biophysical Techniques: The application of spectroscopic and analytical techniques to measure the physical properties of biomolecular systems, including kinetics, coupled assays, biothermodynamic methods (SPR, ITC), fluorescence, vibrational spectroscopy and imaging techniques. 4. Enzymes and Biosynthesis: This section focuses on enzymes, systems and their applications, beginning with an overview of the structures and functions of the different classes of enzyme. Case studies are used to illustrate the application of techniques covered in earlier sections to the study of complex biological systems and processes. Topics covered include specialized catalytic centers, analysis of biosynthetic gene clusters, protein engineering, directed evolution and highlights of recent natural product biosynthesis.

This course emphasizes hands-on laboratory experience and teaches students research background, relevant theories, and basic laboratory techniques relevant to their field of study. Students formulate a research plan, implement it by conducting experiment-based research, and convey the results in scholarly presentations. Students submit a written research report at the end of the course.

This course provides research training for students through the experience of belonging to a specific laboratory at the University of Tokyo. Students carry out an original research project under the guidance of assigned faculty members. Through a full-time commitment, students will be able to improve their research skills by applying the basic principles and knowledge from the literature related to the research questions, and by developing the skills to collect, interpret, and critique data in order to resolve a research question or evaluate a design for a research project. At the conclusion of the program, students submit their final work (paper, presentation, report etc.) as instructed by their lab supervisors

In this course students acquire a broad knowledge base and develop analytical and critical thinking skills. Students actively participate in seminars, read assigned texts and research papers, and analyze research data. Students also discuss results obtained in their own experiments with peers and senior laboratory members.

The course covers various aspects of biosynthesis and bioenergetics.  The course provides students with important information relevant to understanding the living cell as a chemical reactor, focusing on the chemistry of biosynthesis and bioenergetics underpinning this. The chemistry of key metabolic functions including energy-generating processes such as glycolysis, the citric acid cycle, respiration, photosynthesis as well as aspects regarding control of metabolic flux in the cell are looked at in detail. The course includes a detailed look at information flow and molecular machinery of the cell.

A research project that assigns students to expert professors in their proposed research topic. The course takes the students' research capabilities to a more professional level. This can be most closely compared to what is called a supervised research project in the USA.

This course studies the fundamentals and recent progress in the research fields of molecular biology, cell biology, and physiology with plants, animals, and microbes as well as chemistry of biologically active natural products. More than ten Professors and Associate Professors will give lectures weekly to introduce their specific research fields.

The goal of this class is to obtain the background knowledge concerning life science for agricultural and industrial applications as well as the basic principles of biochemistry and biotechnology.

This course emphasizes hands-on laboratory experience and teaches students research background, relevant theories, and basic laboratory techniques relevant to their field of study. Students formulate a research plan, implement it by conducting experiment-based research, and convey the results in scholarly presentations. Students submit a written research report at the end of the course.

The Individual Research Training Senior (IRT Senior) Course is an advanced course of the Individual Research Training B (IRT B) course in the Tohoku University Junior Year Program in English (JYPE) in the spring semester. Though short-term international exchange students are not degree candidates at Tohoku University, a similar experience is offered by special arrangement. Students are required to submit: an abstract concerning the results of their IRT Senior project, a paper (A4, 20-30 pages) on their research at the end of the exchange term, and an oral presentation on the results of their IRT Senior project near the end of the　term.