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This course is part of the Laurea Magistrale degree program and is intended for advanced level students. Enrollment is by permission of the instructor. This course provides students with an advanced knowledge of cellular neurobiology and molecular mechanisms of brain functions, as well as to make students able to apply this knowledge to specific aspects of nervous system physiopathology. This course is an overview of advanced topics in neurobiology and is designed to introduce and discuss the biological models, the techniques and the research strategies employed in this research field, as well as the molecular mechanisms underlying the structure and function of the nervous system. The course is divided into three general topic areas: cell biology of the nervous system, molecular mechanisms in the brain functions, and their alterations in neuropathologies. At the end of the course, the student is able to: understand and discuss properly main aspects of nervous system physiopathology; read and comprehend scientific articles; use this neurobiology background for advances experimental purposes. The course content is divided as follows:
- Advanced Methodological Approaches in Neurobiology: From optogenetics to neuroimaging, brain atlas.
- In Vitro and In Vivo Models in Neurobiology: From primary cultures to brain organoids, with an introduction to related ethical issues.
- Cellular Neurobiology: Cells of the nervous system, their interactions, and communication systems. Biology and physiology of neurons. Oligodendrocytes and the myelin sheath. Astrocytes and microglia.
- Molecular Neurobiology: Biochemical, molecular, and epigenetic mechanisms underlying cognitive brain processes, such as synaptic plasticity, learning, and memory (from invertebrates to mammals).
- Developmental Neurobiology: Molecular mechanisms underlying the origin of various CNS cell types, cell migration, axonal formation, synapse stabilization, activity-dependent CNS development, critical periods, and neural plasticity. Neural stem cells and adult neurogenesis.
- Cellular and Molecular Mechanisms of Brain–Environment Interaction: Gut–brain axis and circadian rhythm regulation.
- Alterations in Cellular and Molecular Neurobiology in Neuropathologies: Neurodegenerative diseases, prion disorders, neurodevelopmental disorders, and neuropsychiatric diseases.
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This course addresses the particularities of production systems of salmonids (salmon and trout) so that students acquire the specific language, understand its biological bases and relate them to commercial production of salmonid species for human consumption. Special emphasis is placed on the activity in Chile, its requirements, characteristics and cultivation systems.
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This course covers materials processing for manufacturing biomaterials, including traditional manufacturing techniques and 3D printing techniques. Students explore how we can produce biomedical materials, implants, and devices using a variety of manufacturing techniques.
Topics include Introduction to materials processing for biomedical applications, Synthesis of starting materials (ceramics and metals), Polymers as a drug delivery system, CAD/CAM process, Metal casting and surface modifications, Colloidal processes, Processes for porous scaffolds, 3D printing applications.
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This course examines the control of normal body function. The specialized organ systems to be studied include the nervous, cardiovascular, muscular, respiratory, kidney and digestive systems.
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This course examines Australia's deadliest animals, providing an appreciation of these animals and the skills to investigate organisms perceived as risks to humans. By investigating snakes, spiders, crocodiles, sharks, octopuses, jellyfish, insects, and ticks, students will assess and evaluate the evidence addressing key questions: Just how dangerous are Australian animals? How much of their deadly reputation is myth? Why, and how, do people get killed by these extraordinary animals? How well do we estimate the risks they pose? How does understanding of the science of how these animals operate help us manage the dangers they pose?
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Laboratory skills are essential for students who want to pursue a Life Science oriented master study. In this course, get acquainted with the basic laboratory skills in biochemistry. Training involves safety and Good Laboratory Practice, as well as some essential biochemical techniques like DNA isolation, enzyme kinetics, absorption spectrophotometry, and protein gel electrophoresis. Determine the presence of sugars and identify the types of sugars in unknown samples, solving a sugar-riddle. Work in teams of two and prepare your own protocol for each practical. This course is designed to be taken in combination with SCI2035 Biochemistry. Students who wish to take this course should concurrently enroll in SCI2035 Biochemistry or have taken SCI2035 Biochemistry prior to enrolling in SKI2086.
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This course presents and deepens key ecological, spatial, and socio-historical concepts to support the understanding of Brazilian reality through the observation and analysis of Brazilian biomes (Amazon, Caatinga, Cerrado, Atlantic Forest, Pampa, and Pantanal). Other objectives include: a) presenting and discussing fundamental concepts for the study of Brazilian biomes and related themes, such as: domain, ecosystem, space, phytophysiognomy, formation, boundary, landscape, region, etc.; b) analyzing and debating what has been done in each of the Brazilian biomes over time, especially in recent decades; c) presenting and critically discussing different aspects of each of the Brazilian biomes, for example: occupation and transformation of landscapes, types of vegetation, data on biological diversity, main species of flora and fauna, conservation units, etc.
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In this course, students examine and integrate general biological and ecological concepts of marine mammals (with special emphasis on pinnipeds and cetaceans). Students characterize the different orders of marine mammals worldwide and identify the species present in Chile, identify and characterize adaptations of marine mammals to the aquatic environment, behavioral strategies, as well as the main research methodologies used in Chile. In the area of conservation, the students examine the main current threats to marine mammals in Chile, measures of mitigation, institutions, and regulations related to management and administration, and become familiar with the application of methodological tools in the field of conservation of these species.
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