Chemistry

The Individual Research Training Senior (IRT Senior) Course is an advanced course of the Individual Research Training B (IRT B) course in the Tohoku University Junior Year Program in English (JYPE) in the spring semester. Though short-term international exchange students are not degree candidates at Tohoku University, a similar experience is offered by special arrangement. Students are required to submit: an abstract concerning the results of their IRT Senior project, a paper (A4, 20-30 pages) on their research at the end of the exchange term, and an oral presentation on the results of their IRT Senior project near the end of the　term.

Intellectual property and patent law in the pharmaceutical industry. An overview of the legal and regulatory framework for drug design and development. Clinical trials: formulation of a drug; phase I, phase II and phase III protocols. An introduction to the principles involved in the Codes of Good Manufacturing Practice and Good Laboratory Practice (quality control and quality assurance procedures) as applied to the manufacture of drug products and the quantification of drugs and metabolites in biological fluids. Examples of drug development. Case studies of selected drugs from design to release.

This course examines chemical reactions involving various types of reactive intermediates. The application of molecular orbital theory will be used to understand the nature of pericyclic reactions and the concept of coordination in main group (including carbon) and transition metal elements. An investigation of inorganic reaction mechanisms will focus on transformations involving coordination and organometallic complexes of d-block metals. Discussion of synthetic aspects will cover methods for carbon-carbon bond formation and functional group transformations, as well as principles of catalysis involving transition metal complexes and their chemistry in synthetic and biological systems.

The course gives an introduction of the biotech pharmaceutical industry and also focuses on the development of biotech medicine, small molecule drug, protein drug, and regulations and business aspects of the industry. Course topics: Biotech Pharmaceutical Industry Overview, Biotechnology entrepreneurship and investment, biotech medicine business success stories, business development strategy of biotech pharmaceutical industry, gene decoding's impact on development of biotech medicine, nanotechnology in biotechnology applications and challenges, intellectual property rights and management, small molecule drug development, protein drug development, clinical trials and regulations, pharmaceutical production and regulations, biotech business enterprises. The course consists of weekly lecture, a midterm, and a final. The course is conducted in Chinese, but uses an English textbook.

This course is divided into two parts. The first part of the course teaches the basic concepts of organic chemistry; in particular, the structure and reactivity relationship (stereochemistry and electronic effects). The second part focuses on chemical reactivity of aliphatic (alkanes, alkenes, alkynes) and aromatic (benzene derivatives) compounds.